Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | ATR | Q13535 | 8/20 | 0.52 |
| ▸ | ATRIP | Q8WXE1 | 7/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.49 |
| ▸ | MTOR | P42345 | 8/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2448685 | 0.91 | CRHBP (0.61) | PDPK1ROCK1AURKBAURKAATR | |
| SCHEMBL1318430 | 0.90 | CYP1A2 (0.60) | PDPK1ROCK1AURKBAURKAATR | |
| SCHEMBL1774685 | 0.85 | HRH3 (0.55) | PDPK1ROCK1AURKBAURKA | |
| SCHEMBL1775307 | 0.85 | HRH3 (0.55) | PDPK1ROCK1AURKBAURKA | |
| SCHEMBL21516848 | 0.82 | CRHBP (0.55) | PDPK1ROCK1AURKBAURKAATR | |
| SCHEMBL21516206 | 0.82 | CRHBP (0.55) | PDPK1ROCK1AURKBAURKAATR | |
| SCHEMBL3081642 | 0.81 | MTOR (0.54) | ATRATRIPCHEK1PDCD1CD274 | |
| SCHEMBL3723256 | 0.81 | PDCD1 (0.56) | PDPK1ROCK1AURKBAURKAATR | |
| SCHEMBL3723251 | 0.81 | PDCD1 (0.56) | PDPK1ROCK1AURKBAURKAATR | |
| SCHEMBL21263111 | 0.80 | ATR (0.53) | PDPK1ROCK1AURKBAURKAATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100227858-A1 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2010-09-09 | — | — | US | disclosed |
| US-20100227858-A1 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2010-09-09 | — | — | US | disclosed |
| US-20100227858-A1 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2010-09-09 | — | — | US | disclosed |
| WO-2009007751-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227858-A1 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | MTOR, PIK3CA, PIK3CD | PDPK1 7/4885ROCK1 1733/4885AURKB 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.