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SCHEMBL2472153

SCHEMBL2472153

COC(=O)C(C(=O)OC)C(=O)c1ccc(Cl)cc1SC(=O)N(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.39
▸ HTT P42858 1/20 0.39
▸ ABL1 P00519 1/20 0.38
▸ ALDH1A1 P00352 9/20 0.37
▸ MAPT P10636 2/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ CYP1A2 P05177 2/20 0.34
▸ CYP2C19 P33261 2/20 0.34
▸ GAA P10253 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ NPC1 O15118 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ AHR P35869 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ FSCN1 Q16658 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27864706 0.88 ALDH1A1 (0.39) HPGDHTTABL1ALDH1A1MAPT
SCHEMBL2471737 0.85 NCEH1 (0.36) HPGDHTTALDH1A1MEN1KMT2A
SCHEMBL2472156 0.83 ALDH1A1 (0.36) HPGDHTTALDH1A1MAPTGAA
SCHEMBL2473934 0.82 ABL1 (0.53) HPGDHTTABL1ALDH1A1MAPT
SCHEMBL2472875 0.78 SMN1; SMN2 (0.49) HPGDHTTALDH1A1MAPTMEN1
SCHEMBL2472955 0.77 NPSR1 (0.38) HPGDHTTALDH1A1MAPTCYP1A2
SCHEMBL13159056 0.74 ABL1 (0.49) HPGDHTTABL1ALDH1A1MAPT
SCHEMBL27864810 0.69 ALDH1A1 (0.36) HPGDHTTABL1ALDH1A1MAPT
SCHEMBL2471739 0.68 ALDH1A1 (0.36) ALDH1A1MAPTMEN1KMT2AGAA
SCHEMBL6560067 0.68 MT-CO2 (0.40) HPGDTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2370422-B1 THIOCHROMENE DERIVATIVES AS HIF HYDROXYLASE INHIBITORS FIBROGEN INC (US) 2019-06-05 — — EP disclosed
US-9149476-B2 Thiochromene derivatives as HIF hydroxylase inhibitors FIBROGEN, INC. (US) 2015-10-06 — — US disclosed
US-20150182528-A1 THIOCHROMENE DERIVATIVES AS HIF HYDROXYLASE INHIBITORS FIBROGEN, INC. 2015-07-02 — — US disclosed
US-8927591-B2 Thiochromene derivatives as HIF hydroxylase inhibitors FIBROGEN, INC. (US) 2015-01-06 — — US disclosed
US-20110305776-A1 THIOCHROMENE DERIVATIVES AS HIF HYDROXYLASE INHIBITORS FIBROGEN, INC. (US) 2011-12-15 — — US disclosed
EP-2370422-A1 THIOCHROMENE DERIVATIVES AS HIP HYDROXYLASE INHIBITORS Fibrogen, Inc. (US) 2011-10-05 — — EP disclosed
WO-2010056767-A1 THIOCHROMENE DERIVATIVES AS HIP HYDROXYLASE INHIBITORS FIBROGEN, INC. (US) 2010-05-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110305776-A1 THIOCHROMENE DERIVATIVES AS HIF HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 HPGD 79/4885HTT 909/4885ABL1 558/4885
US-20150182528-A1 THIOCHROMENE DERIVATIVES AS HIF HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 HPGD 79/4885HTT 909/4885ABL1 558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.