Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2472342 | 0.88 | AVPR1A (0.33) | AVPR1ACYP11B2 | |
| Hydrochloric Acid SCHEMBL2472118 | 0.86 | HTR2C (0.34) | HTR1ASLC6A2 | |
| SCHEMBL2564607 | 0.86 | AVPR1A (0.35) | AVPR1ACYP11B2CYP11B1 | |
| SCHEMBL2475282 | 0.86 | AVPR1A (0.38) | AVPR1ACYP11B2CYP11B1TYRO3 | |
| SCHEMBL2474933 | 0.85 | AVPR1A (0.39) | AVPR1A | |
| SCHEMBL2472064 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL2473468 | 0.84 | OGA (0.32) | CYP11B2 | |
| SCHEMBL2566668 | 0.83 | AVPR1A (0.33) | AVPR1ACYP11B2CYP11B1 | |
| Hydrochloric Acid SCHEMBL2472292 | 0.83 | HSD11B1 (0.31) | AVPR1A | |
| SCHEMBL2469536 | 0.82 | AVPR1A (0.36) | AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035939-A1 | V1A ANTAGONISTS TO TREAT PHASE SHIFT SLEEP DISORDERS | F. Hoffmann-La Roche AG (CH) | 2016-06-29 | — | — | EP | claimed |
| WO-2015024819-A1 | V1A ANTAGONISTS TO TREAT PHASE SHIFT SLEEP DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | claimed |
| EP-2370441-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-10-05 | — | — | EP | claimed |
| WO-2010060836-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-03 | — | — | WO | claimed |
| EP-2370441-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010060836-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-03 | — | — | WO | disclosed |