Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6368447 | 0.90 | CRBN (0.51) | CRBNCHEK1AURKADAPK3PRKD3 | |
| SCHEMBL728499 | 0.81 | ABL1 (0.58) | CRBNCHEK1AURKADAPK3PRKD3 | |
| SCHEMBL1092914 | 0.80 | CRBN (0.43) | CRBNMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL25707328 | 0.80 | CRBN (0.43) | CRBNMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL15595069 | 0.79 | CHEK1 (0.39) | CRBNCHEK1AURKADAPK3PRKD3 | |
| SCHEMBL13564019 | 0.77 | MB (0.41) | CRBNCHEK1AURKADAPK3PRKD3 | |
| SCHEMBL19228501 | 0.76 | CRBN (0.40) | CRBNCHEK1AURKADAPK3PRKD3 | |
| SCHEMBL13564008 | 0.74 | ALDH1A1 (0.40) | CRBNCHEK1AURKADAPK3PRKD3 | |
| SCHEMBL18068308 | 0.74 | NNMT (0.55) | MAPT | |
| SCHEMBL1104639 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187329-A1 | FABI INHIBITORS FOR GRAM-NEGATIVE PATHOGENS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2022-09-09 | — | — | WO | disclosed |