SCHEMBL247233

SCHEMBL247233

O=C1C[C@H](O)C[C@@H](/C=C/c2c(C3CC3)nc3ccccc3c2-c2ccc(F)cc2)O1

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 10/20 0.74
RXRA P19793 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9301248 1.00 HMGCR (0.74) HMGCRRXRA
SCHEMBL247234 1.00 HMGCR (0.74) HMGCRRXRA
SCHEMBL7481310 1.00 HMGCR (0.74) HMGCRRXRA
SCHEMBL7481306 1.00 HMGCR (0.74) HMGCRRXRA
SCHEMBL10049194 0.89 HMGCR (0.60) HMGCRRXRA
SCHEMBL13847591 0.89 HMGCR (0.66) HMGCR
SCHEMBL13994086 0.88 HMGCR (0.61) HMGCR
SCHEMBL13524825 0.88 HMGCR (0.65) HMGCR
SCHEMBL13994087 0.88 HMGCR (0.65) HMGCR
SCHEMBL14207592 0.88 HMGCR (0.61) HMGCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115792001-B Analytical method for determining pitavastatin tert-butyl ester related substances by utilizing HPLC 徐州万邦金桥制药有限公司 2025-05-09 CN claimed
CN-115792001-A Analysis method for determining pitavastatin tert-butyl ester related substances by using HPLC 徐州万邦金桥制药有限公司 2023-03-14 CN claimed
US-8853405-B2 Crystalline forms of pitavastatin calcium NISSAN CHEMICAL INDUSTRIES LTD. (JP) 2014-10-07 US claimed
US-20140005402-A1 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-01-02 US claimed
CN-120000601-A Pitavastatin calcium orally disintegrating tablet composition as well as preparation method and application thereof 广东万泰科创药业有限公司 2025-05-16 CN disclosed
CN-115792001-B Analytical method for determining pitavastatin tert-butyl ester related substances by utilizing HPLC 徐州万邦金桥制药有限公司 2025-05-09 CN disclosed
CN-115792001-A Analysis method for determining pitavastatin tert-butyl ester related substances by using HPLC 徐州万邦金桥制药有限公司 2023-03-14 CN disclosed
EP-1472227-B1 PROCESS FOR THE MANUFACTURE OF ORGANIC COMPOUNDS NOVARTIS AG (CH) 2016-04-27 EP disclosed
US-8487105-B2 Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof MSN LABORATORIES LIMITED (IN) 2013-07-16 US disclosed
US-8487105-B2 Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof MSN LABORATORIES LIMITED (IN) 2013-07-16 US disclosed
US-8476432-B2 Process for the preparation of HMG-COA reductase inhibitors and intermediates thereof YUHAN CORPORATION (KR) 2013-07-02 US disclosed
EP-2588474-A2 PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF Yuhan Corporation (KR) 2013-05-08 EP disclosed
WO-1995011898-A1 CONDENSED PYRIDINE TYPE MEVALONOLACTONE INTERMEDIATE AND PROCESS FOR ITS PRODUCTION NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1995-05-04 WO disclosed
US-5369109-A Optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids SAGAMI CHEMICAL RESEARCH CENTER (JP) 1994-11-29 US disclosed
EP-0475627-B1 Optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids SAGAMI CHEM RES (JP) 1994-10-19 EP disclosed
US-5284953-A Treatment and prevention of hyperlipemia and arteriosclerosis NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1994-02-08 US disclosed
US-5276154-A Optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids SAGAMI CHEMICAL RESEARCH CENTER (JP) 1994-01-04 US disclosed
EP-0535548-A1 Inhibitor of atherosclerotic intimal thickening NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1993-04-07 EP disclosed
EP-0520406-A1 Diastereomer salt of optically active quinolinemevalonic acid NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1992-12-30 EP disclosed
EP-0475627-A1 Optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids SAGAMI CHEMICAL RESEARCH CENTER (JP) 1992-03-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140005402-A1 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM CTSC, CACYBP, CA4 HMGCR 345/4885RXRA 3154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.