SCHEMBL7481306

SCHEMBL7481306

O=C1CC(O)CC(/C=C/c2c(C3CC3)nc3ccccc3c2-c2ccc(F)cc2)O1

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 10/20 0.74
RXRA P19793 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9301248 1.00 HMGCR (0.74) HMGCRRXRA
SCHEMBL247234 1.00 HMGCR (0.74) HMGCRRXRA
SCHEMBL7481310 1.00 HMGCR (0.74) HMGCRRXRA
SCHEMBL247233 1.00 HMGCR (0.74) HMGCRRXRA
SCHEMBL10049194 0.89 HMGCR (0.60) HMGCRRXRA
SCHEMBL13847591 0.89 HMGCR (0.66) HMGCR
SCHEMBL13994086 0.88 HMGCR (0.61) HMGCR
SCHEMBL13524825 0.88 HMGCR (0.65) HMGCR
SCHEMBL13994087 0.88 HMGCR (0.65) HMGCR
SCHEMBL14207592 0.88 HMGCR (0.61) HMGCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115792001-A Analysis method for determining pitavastatin tert-butyl ester related substances by using HPLC 徐州万邦金桥制药有限公司 2023-03-14 CN claimed
CN-115792001-A Analysis method for determining pitavastatin tert-butyl ester related substances by using HPLC 徐州万邦金桥制药有限公司 2023-03-14 CN disclosed
US-20140140931-A1 ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER CEDARS-SINAI MEDICAL CENTER (US) 2014-05-22 US disclosed
US-20140140931-A1 ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER CEDARS-SINAI MEDICAL CENTER (US) 2014-05-22 US disclosed
US-20140105822-A1 NANOSPHERES COMPRISING TOCOPHEROL, AN AMPHIPHILIC SPACER AND A THERAPEUTIC OR IMAGING AGENT CEDARS-SINAI MEDICAL CENTER (US) 2014-04-17 US disclosed
US-20140105822-A1 NANOSPHERES COMPRISING TOCOPHEROL, AN AMPHIPHILIC SPACER AND A THERAPEUTIC OR IMAGING AGENT CEDARS-SINAI MEDICAL CENTER (US) 2014-04-17 US disclosed
WO-2013016696-A1 ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER CEDARS-SINAI MEDICAL CENTER (US) 2013-01-31 WO disclosed
WO-2011105649-A1 NEW METHOD FOR MANUFACTURING PITAVASTATIN HEMICALCIUM USING NEW INTERMEDIATE (주)메디켐코리아 (KR) 2011-09-01 WO disclosed
US-7193086-B2 Process for preparation of a quinolinecarbaldehyde NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2007-03-20 US disclosed
US-7193086-B2 Process for preparation of a quinolinecarbaldehyde NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2007-03-20 US disclosed
EP-0747341-B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE MEVALONOLACTONE COMPOUNDS DAICEL CHEM (JP) 2002-05-22 EP disclosed
EP-0747341-A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE MEVALONOLACTONE COMPOUND DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1996-12-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140105822-A1 NANOSPHERES COMPRISING TOCOPHEROL, AN AMPHIPHILIC SPACER AND A THERAPEUTIC OR IMAGING AGENT TTPA, NFE2, GSTK1 HMGCR 4/4885RXRA 406/4885
US-20140140931-A1 ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER NLN, CASP12, GPX4 HMGCR 8/4885RXRA 1368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.