Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542710 | 0.87 | MAPT (0.48) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL11493538 | 0.81 | SMN1; SMN2 (0.56) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL11571840 | 0.81 | MAPT (0.86) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL29129826 | 0.79 | MAPT (0.74) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL30694320 | 0.79 | MAPT (0.74) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9487708 | 0.78 | SMN1; SMN2 (0.53) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL18054756 | 0.77 | MAPT (0.70) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL18554238 | 0.76 | NPSR1 (0.62) | ALDH1A1LMNACYP1A2CYP2C9TP53 | |
| SCHEMBL27611956 | 0.76 | MAPT (0.72) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL31384417 | 0.75 | MAPT (0.67) | MAPTALDH1A1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858520-B1 | QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME (US) | 2011-10-05 | — | — | EP | disclosed |
| EP-0530994-A1 | Quinazoline derivatives as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1993004047-A1 | QUINAZOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-04 | — | — | WO | disclosed |