Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.70 |
| ▸ | DPP7 | Q9UHL4 | 13/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.70 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.70 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13342409 | 0.85 | DPP4 (0.87) | DPP4DPP7KCNH2DPP9DPP8 | |
| SCHEMBL3535584 | 0.85 | DPP4 (0.87) | DPP4DPP7KCNH2DPP9DPP8 | |
| SCHEMBL2471776 | 0.84 | DPP4 (0.55) | DPP4DPP7KCNH2DPP9DPP8 | |
| SCHEMBL3533164 | 0.83 | DPP4 (0.72) | DPP4DPP7KCNH2DPP9DPP8 | |
| Trifluoroacetic Acid SCHEMBL2467033 | 0.82 | DPP4 (1.00) | DPP4DPP7KCNH2DPP9DPP8 | |
| SCHEMBL2470438 | 0.80 | DPP4 (0.51) | DPP4DPP7KCNH2DPP9DPP8 | |
| SCHEMBL2472453 | 0.73 | DPP4 (0.42) | DPP4DPP7KCNH2DPP9CYP2D6 | |
| SCHEMBL21067325 | 0.71 | DPP4 (1.00) | DPP4DPP7KCNH2DPP9DPP8 | |
| SCHEMBL8259100 | 0.71 | DPP4 (1.00) | DPP4DPP7KCNH2DPP9DPP8 | |
| SCHEMBL3532200 | 0.68 | DPP4 (0.58) | DPP4DPP7KCNH2DPP9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819674-B1 | FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2011-10-05 | — | — | EP | disclosed |