Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4B | O94953 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933097 | 0.83 | NAMPT (0.49) | NAMPTTLR9TLR8TLR7SLC18A3 | |
| SCHEMBL25030606 | 0.79 | SLC18A3 (0.40) | KDM4ESMN1; SMN2GLAHTTKMT2A | |
| SCHEMBL24724945 | 0.78 | NAMPT (0.43) | NAMPTKDM4ESMN1; SMN2KDM4AKDM4B | |
| SCHEMBL24933096 | 0.77 | PARP1 (0.43) | KMT2ACYP2D6 | |
| SCHEMBL12367648 | 0.75 | TACR3 (0.41) | NAMPTKDM4ESMN1; SMN2TDP1TLR9 | |
| SCHEMBL27282972 | 0.72 | KDM4E (0.59) | NAMPTKDM4ESMN1; SMN2GLAHTT | |
| SCHEMBL12367652 | 0.72 | KDM4E (0.42) | NAMPTKDM4ESMN1; SMN2TACR3CYP2D6 | |
| SCHEMBL24724942 | 0.70 | ESRRG (0.45) | SLC18A3 | |
| SCHEMBL23374690 | 0.70 | SLC18A3 (0.49) | NAMPTTLR9TLR8TLR7SLC18A3 | |
| SCHEMBL20038345 | 0.69 | SLC18A3 (0.46) | TLR9TLR8TLR7SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009554-A1 | METHODS TO REDUCE ADVERSE EFFECTS OF GENE OR BIOLOGICS THERAPY | AVILAR THERAPEUTICS, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022235699-A2 | POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |