Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | WNT1 | P04628 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933098 | 0.89 | DRD4 (0.42) | DRD4DRD2SMN1; SMN2FASN | |
| SCHEMBL24933097 | 0.80 | NAMPT (0.49) | NAMPTDRD2ALDH1A1CYP2D6HRH3 | |
| SCHEMBL24724937 | 0.78 | NAMPT (0.47) | NAMPTKDM4ESMN1; SMN2GSK3BDYRK1A | |
| SCHEMBL24724941 | 0.77 | KMT2A (0.44) | DRD4DRD2KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL13490363 | 0.70 | FDFT1 (0.48) | DRD4DRD2KDM4EHRH3 | |
| SCHEMBL24725714 | 0.69 | KMT2A (0.51) | KDM4ESMN1; SMN2ALDH1A1HRH3 | |
| SCHEMBL17660282 | 0.69 | MAPK14 (0.52) | NAMPTKDM4E | |
| SCHEMBL24725715 | 0.68 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1HRH3 | |
| SCHEMBL24724942 | 0.68 | ESRRG (0.45) | DRD2ALDH1A1 | |
| SCHEMBL12418685 | 0.68 | P4HTM (0.57) | KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235699-A2 | POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |