Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SHCN4KCNJ2SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Dronedarone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | DRD1 | P21728 | 1/20 | 0.98 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.98 |
| ▸ | PDE4A | P27815 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.98 |
| ▸ | DRD3 | P35462 | 1/20 | 0.98 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.98 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dronedarone SCHEMBL2473281 | 0.99 | ESR1 (0.97) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL110363 | 0.99 | ESR1 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL4540209 | 0.99 | ESR1 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL29533002 | 0.99 | ESR1 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL18074257 | 0.98 | ABCB11 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL28179052 | 0.98 | ESR1 (0.98) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL321382 | 0.98 | ESR1 (0.98) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL223035 | 0.98 | ABCB11 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL29620421 | 0.98 | ABCB11 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL322530 | 0.97 | ABCB11 (0.98) | ESR1PGRCHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371824-A1 | Crystalline dronedarone salts | Ratiopharm GmbH (DE) | 2011-10-05 | — | — | EP | claimed |
| CN-102471302-B | Preparation process of dronedarone and its salts | JIANGSU HENGRUI MEDICINE CO | 2014-03-26 | — | — | CN | disclosed |
| US-8481763-B2 | Preparation process of dronedarone and its salts | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-07-09 | — | — | US | disclosed |
| EP-2581369-A1 | PREPARATION PROCESS OF DRONEDARONE AND ITS SALTS | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2013-04-17 | — | — | EP | disclosed |
| US-20130072697-A1 | PREPARATION PROCESS OF DRONEDARONE AND ITS SALTS | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-03-21 | — | — | US | disclosed |
| CN-102471302-A | Preparation process of dronedarone and its salts | JIANGSU HENGRUI MEDICINE CO | 2012-05-23 | — | — | CN | disclosed |
| CN-102276561-A | Preparation method of Dronedarone and its salt | — | 2011-12-14 | — | — | CN | disclosed |
| EP-2371824-A1 | Crystalline dronedarone salts | Ratiopharm GmbH (DE) | 2011-10-05 | — | — | EP | disclosed |
| EP-2371808-A1 | Process for preparing dronedarone | Ratiopharm GmbH (DE) | 2011-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072697-A1 | PREPARATION PROCESS OF DRONEDARONE AND ITS SALTS | CYP2D6, CYP3A4, CYP2C9 | ESR1 4215/4885PGR 4244/4885CHRM2 4423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.