Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SHCN4KCNJ2SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Dronedarone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | DRD1 | P21728 | 1/20 | 0.98 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.98 |
| ▸ | PDE4A | P27815 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.98 |
| ▸ | DRD3 | P35462 | 1/20 | 0.98 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.98 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dronedarone SCHEMBL322530 | 0.99 | ABCB11 (0.98) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL110363 | 0.99 | ESR1 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL29533002 | 0.99 | ESR1 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL4540209 | 0.99 | ESR1 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL18074257 | 0.98 | ABCB11 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL2472589 | 0.98 | ESR1 (0.98) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL223035 | 0.98 | ABCB11 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL29620421 | 0.98 | ABCB11 (1.00) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL28179052 | 0.98 | ESR1 (0.98) | ESR1PGRCHRM2HTR1AADRA2A | |
| Dronedarone SCHEMBL22527644 | 0.97 | ESR1 (0.97) | ESR1PGRCHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012032545-A1 | PROCESSES FOR PREPARING DRONEDARONE AND ITS INTERMEDIATES | CADILA HEALTHCARE LIMITED (IN) | 2012-03-15 | — | — | WO | claimed |
| WO-2012004658-A2 | PROCESS FOR PREPARATION OF N-[2-BUTYL-3-[4-[3-(DIBUTYLAMINO)PROPOXY]BENZOYL]-5-BENZOFURANYL]METHANESULFONAMIDE, ACID ADDITION SALTS AND PRODUCT THEREOF | FRICHEM PRIVATE LIMITED (IN) | 2012-01-12 | — | — | WO | claimed |
| WO-2012032545-A1 | PROCESSES FOR PREPARING DRONEDARONE AND ITS INTERMEDIATES | CADILA HEALTHCARE LIMITED (IN) | 2012-03-15 | — | — | WO | disclosed |
| WO-2012004658-A2 | PROCESS FOR PREPARATION OF N-[2-BUTYL-3-[4-[3-(DIBUTYLAMINO)PROPOXY]BENZOYL]-5-BENZOFURANYL]METHANESULFONAMIDE, ACID ADDITION SALTS AND PRODUCT THEREOF | FRICHEM PRIVATE LIMITED (IN) | 2012-01-12 | — | — | WO | disclosed |