SCHEMBL24726482

SCHEMBL24726482

c1ccc(-c2cccc([C@H]3CCON3)c2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 1/20 0.37
PRKACA P17612 1/20 0.36
PRKACG P22612 1/20 0.36
PRKACB P22694 1/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 2/20 0.36
GAA P10253 2/20 0.36
KMT2A Q03164 2/20 0.36
HTR2B P41595 5/20 0.34
HTR2A P28223 4/20 0.34
HTR2C P28335 4/20 0.34
MAOA P21397 2/20 0.34
HRH3 Q9Y5N1 2/20 0.34
KDM1A O60341 1/20 0.34
GABRA1 P14867 2/20 0.33
GABRB2 P47870 1/20 0.33
NOTUM Q6P988 1/20 0.33
HTR7 P34969 2/20 0.33
SIGMAR1 Q99720 2/20 0.33
GABRG2 P18507 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30678295 1.00 SLC5A2 (0.37) SLC5A2PRKACAPRKACGPRKACBKDM4E
SCHEMBL29729987 1.00 SLC5A2 (0.37) SLC5A2PRKACAPRKACGPRKACBKDM4E
SCHEMBL30678222 0.86 TAAR1 (0.38) HTR2CNOTUMNISCHNPC1
SCHEMBL30064179 0.84 PRKACA (0.33) PRKACAPRKACGPRKACBHTR2CNOTUM
SCHEMBL30064160 0.84 PRKACA (0.33) PRKACAPRKACGPRKACBHTR2CNOTUM
SCHEMBL30678266 0.84 PRKACA (0.46) PRKACAPRKACGPRKACBHRH3GABRA1
SCHEMBL27169345 0.84 PRKACA (0.46) PRKACAPRKACGPRKACBHRH3GABRA1
SCHEMBL30678224 0.84 KIF11 (0.41) MEN1KMT2AHTR2CMAOAKDM1A
SCHEMBL27169307 0.84 KMO (0.47) KDM4EGAA
SCHEMBL27169351 0.84 PRKACA (0.46) PRKACAPRKACGPRKACBHRH3GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022234965-A1 HETEROARYL DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT 주식회사 보로노이 2022-11-10 WO disclosed