SCHEMBL24728239

SCHEMBL24728239

COc1cc(/C=C/C(=O)c2cc3ccc4c(c3o2)C=CC(C)(C)O4)cc(OC)c1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.55
ODC1 P11926 3/20 0.52
HIF1AN Q9NWT6 2/20 0.52
NFKB1 P19838 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47
PTPN1 P18031 3/20 0.46
BCHE P06276 1/20 0.46
BACE1 P56817 1/20 0.46
HIF1A Q16665 2/20 0.42
PDE4D Q08499 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29822997 1.00 ACHE (0.55) ACHEODC1HIF1ANNFKB1NFKB2
SCHEMBL24728324 0.92 ACHE (0.66) ACHEODC1HIF1ANNFKB1NFKB2
SCHEMBL24728311 0.91 MAOB (0.53) ACHEODC1HIF1ANBCHEHIF1A
SCHEMBL24728218 0.88 ODC1 (0.57) ACHEODC1HIF1ANNFKB1NFKB2
SCHEMBL29822893 0.88 ODC1 (0.57) ACHEODC1HIF1ANNFKB1NFKB2
SCHEMBL24728166 0.85 PTPN1 (0.52) ACHEODC1HIF1ANNFKB1NFKB2
SCHEMBL29822581 0.85 TNFRSF1A (0.50) ACHEODC1HIF1ANNFKB1NFKB2
SCHEMBL24728330 0.85 TNFRSF1A (0.50) ACHEODC1HIF1ANNFKB1NFKB2
SCHEMBL24728303 0.83 HIF1AN (0.51) ACHEODC1HIF1ANNFKB1NFKB2
SCHEMBL29822826 0.83 HIF1AN (0.51) ACHEODC1HIF1ANNFKB1NFKB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022158624-A1 NOVEL BENZOPYRAN DERIVATIVE COMPOUND, PREPARATION METHOD THEREFOR, AND ANTICANCER COMPOSITION COMPRISING SAME 연세대학교 산학협력단 2022-07-28 WO disclosed