Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 3/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248722 | 0.82 | MAP4K4 (0.39) | HTTSMN1; SMN2LMNAMAPK1RAB9A | |
| SCHEMBL4443536 | 0.81 | PIK3CD (0.42) | HTTSMN1; SMN2LMNAMAPK1TAAR1 | |
| SCHEMBL17240937 | 0.81 | PIK3CG (0.52) | HTTSMN1; SMN2LMNAMAPK1TAAR1 | |
| Water SCHEMBL17240976 | 0.80 | PIK3CG (0.51) | HTTSMN1; SMN2LMNAMAPK1TAAR1 | |
| SCHEMBL4436542 | 0.79 | MAPK1 (0.39) | HTTSMN1; SMN2LMNAMAPK1TAAR1 | |
| SCHEMBL4442906 | 0.78 | METAP1 (0.40) | HTTSMN1; SMN2LMNAMAPK1TAAR1 | |
| SCHEMBL14815336 | 0.78 | PIK3CD (0.51) | RAB9APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL247286 | 0.78 | PIK3CD (0.51) | RAB9APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14815568 | 0.78 | PIK3CD (0.51) | RAB9APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16799174 | 0.78 | PIK3CG (0.41) | HTTSMN1; SMN2LMNAMAPK1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003262-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |