Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443536 | 0.87 | PIK3CD (0.42) | METAP1L3MBTL1KMT2AHTTLMNA | |
| SCHEMBL16799174 | 0.83 | PIK3CG (0.41) | METAP1L3MBTL1JAK2PPP1CAKMT2A | |
| SCHEMBL4437114 | 0.83 | MAP4K4 (0.41) | JAK2KMT2AHTTLMNAMAPK1 | |
| SCHEMBL17240937 | 0.81 | PIK3CG (0.52) | METAP1L3MBTL1HTTLMNAMAPK1 | |
| Water SCHEMBL17240976 | 0.80 | PIK3CG (0.51) | METAP1L3MBTL1HTTLMNAMAPK1 | |
| SCHEMBL4175693 | 0.79 | LMNA (0.42) | HTTLMNAMAPK1EGFRHIF1A | |
| SCHEMBL4167683 | 0.79 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL247287 | 0.78 | HTT (0.41) | METAP1L3MBTL1JAK2PPP1CAKMT2A | |
| SCHEMBL4436542 | 0.78 | MAPK1 (0.39) | METAP1L3MBTL1KMT2AHTTLMNA | |
| SCHEMBL4181317 | 0.78 | PIK3CD (0.43) | HTTLMNAHIF1ASYKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |