Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 8/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433351 | 0.84 | MAP4K4 (0.41) | MAP4K4AURKAAURKBJAK2JAK3 | |
| SCHEMBL4435767 | 0.83 | MAP4K4 (0.40) | MAP4K4AURKAAURKBJAK2JAK3 | |
| SCHEMBL247287 | 0.82 | HTT (0.41) | JAK2RAB9ASMN1; SMN2LMNAHTT | |
| SCHEMBL4437114 | 0.80 | MAP4K4 (0.41) | MAP4K4AURKAAURKBJAK2JAK3 | |
| SCHEMBL248721 | 0.79 | PIK3CD (0.46) | MAP4K4PIK3CD | |
| SCHEMBL4436316 | 0.78 | MAP4K4 (0.39) | MAP4K4AURKAAURKBJAK2JAK3 | |
| SCHEMBL16799113 | 0.78 | LMNA (0.39) | MAP4K4AURKAAURKBJAK2JAK3 | |
| SCHEMBL4434824 | 0.77 | LMNA (0.42) | MAP4K4AURKAAURKBJAK3PRKD3 | |
| SCHEMBL2015901 | 0.75 | MAPK1 (0.48) | MAP4K4AURKAAURKBJAK2JAK3 | |
| SCHEMBL4435013 | 0.75 | PIK3CD (0.37) | MAP4K4AURKAAURKBJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003262-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |