Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 11/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.49 |
| ▸ | F11 | P03951 | 1/20 | 0.44 |
| ▸ | MASP2 | O00187 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17232504 | 0.84 | F2 (0.49) | F2NOTUMF11MASP2CYP3A4 | |
| SCHEMBL642471 | 0.84 | F2 (0.49) | F2NOTUMF11MASP2CYP3A4 | |
| Hydrochloric Acid SCHEMBL641657 | 0.83 | F2 (0.47) | F2NOTUMF11MASP2CYP3A4 | |
| Hydrochloric Acid SCHEMBL29880447 | 0.83 | F2 (0.47) | F2NOTUMF11MASP2CYP3A4 | |
| SCHEMBL30711653 | 0.82 | F11 (0.48) | F2NOTUMF11MASP2CYP3A4 | |
| SCHEMBL27033841 | 0.82 | F11 (0.48) | F2NOTUMF11MASP2CYP3A4 | |
| SCHEMBL10290444 | 0.82 | F2 (0.46) | F2NOTUMF11MASP2CYP3A4 | |
| SCHEMBL3004861 | 0.82 | F2 (0.46) | F2NOTUMF11MASP2CYP3A4 | |
| SCHEMBL30711643 | 0.81 | F2 (0.47) | F2NOTUMF11MASP2CYP3A4 | |
| SCHEMBL27033847 | 0.81 | F2 (0.47) | F2NOTUMF11MASP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308227-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396473-A | Imidazopyridinyl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |