Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 8/20 | 0.35 |
| ▸ | KDR | P35968 | 7/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18084612 | 1.00 | HRH3 (0.44) | HRH3IRAK4PDK1EPHA2KDR | |
| SCHEMBL24731127 | 1.00 | HRH3 (0.44) | HRH3IRAK4PDK1EPHA2KDR | |
| SCHEMBL19465223 | 0.87 | HRH3 (0.42) | HRH3IRAK4PDK1DRD4 | |
| SCHEMBL23979785 | 0.84 | HRH3 (0.43) | HRH3IRAK4PDK1EPHA2KDR | |
| SCHEMBL23592553 | 0.84 | HRH3 (0.33) | HRH3IRAK4PDK1 | |
| SCHEMBL27323714 | 0.81 | HRH3 (0.58) | HRH3PDK1EPHA2KDREPHB4 | |
| SCHEMBL17827404 | 0.81 | HRH3 (0.58) | HRH3PDK1EPHA2KDREPHB4 | |
| SCHEMBL25001428 | 0.81 | HRH3 (0.38) | HRH3PDK1DRD4 | |
| SCHEMBL7925158 | 0.79 | PDK1 (0.56) | HRH3PDK1EPHA2KDREPHB4 | |
| SCHEMBL3436781 | 0.79 | PDK1 (0.56) | HRH3PDK1EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242552-A1 | Nitrogen-Containing Heterocyclic Compound, Preparation Method Therefor and Use Thereof | 280 Bio, Inc (US) | 2023-08-03 | — | — | US | disclosed |
| WO-2022247770-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海璎黎药业有限公司 | 2022-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242552-A1 | Nitrogen-Containing Heterocyclic Compound, Preparation Method Therefor and Use Thereof | NRAS, KRAS, RAB8A | HRH3 2019/4885IRAK4 3957/4885PDK1 2432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.