Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | ME2 | P23368 | 1/20 | 0.40 |
| ▸ | ME1 | P48163 | 1/20 | 0.40 |
| ▸ | ME3 | Q16798 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13183014 | 1.00 | NPC1 (0.44) | NPC1TDP1POLBKDM1AFKBP1A | |
| SCHEMBL14312307 | 0.84 | NPC1 (0.41) | NPC1TDP1POLBKDM1AFKBP1A | |
| SCHEMBL2473644 | 0.84 | NPC1 (0.49) | NPC1TDP1POLBKDM1AFKBP1A | |
| SCHEMBL2473648 | 0.82 | EPHX2 (0.49) | NPC1TDP1POLBKDM1AFKBP1A | |
| SCHEMBL2471495 | 0.79 | ALDH1A1 (0.58) | NPC1TDP1POLBKDM1AFKBP1A | |
| SCHEMBL2467137 | 0.77 | EPHX2 (0.46) | POLBKDM1AKMT2AGFERMEN1 | |
| SCHEMBL2519479 | 0.76 | GAA (0.49) | KMT2AGFERMEN1EPHX2 | |
| SCHEMBL13688315 | 0.76 | CHRM5 (0.60) | NPC1TDP1POLBKDM1AFKBP1A | |
| SCHEMBL2469785 | 0.75 | CCR8 (0.54) | KMT2A | |
| SCHEMBL6418630 | 0.75 | MMP9 (0.51) | MMP9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371366-A1 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |