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Sugi Predict / Compounds / SCHEMBL2473482

SCHEMBL2473482

SCHEMBL2473482

COC(=O)C(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)NC(=O)CN(CC(=O)O)Cc1ccc(C)cc1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ SIRT2 Q8IXJ6 13/20 0.58
▸ MDM4 O15151 1/20 0.40
▸ MDM2 Q00987 1/20 0.40
▸ ATM Q13315 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ NMBR P28336 1/20 0.39
▸ OPRK1 P41145 1/20 0.38
▸ MEN1 O00255 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2473478 1.00 SIRT2 (0.58) SIRT2MDM4MDM2ATML3MBTL1
SCHEMBL2476422 0.95 SIRT2 (0.61) SIRT2MDM4MDM2NMBROPRK1
SCHEMBL2477239 0.95 SIRT2 (0.61) SIRT2MDM4MDM2NMBROPRK1
SCHEMBL2476426 0.95 SIRT2 (0.61) SIRT2MDM4MDM2NMBROPRK1
SCHEMBL2472234 0.93 SIRT2 (0.57) SIRT2MDM4MDM2NMBROPRK1
SCHEMBL2472238 0.93 SIRT2 (0.57) SIRT2MDM4MDM2NMBROPRK1
SCHEMBL2476117 0.92 SIRT2 (0.56) SIRT2MDM4MDM2NMBROPRK1
SCHEMBL2476116 0.92 SIRT2 (0.56) SIRT2MDM4MDM2NMBROPRK1
SCHEMBL2475599 0.87 SIRT2 (0.53) SIRT2NMBR
SCHEMBL2475588 0.87 SIRT2 (0.53) SIRT2NMBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2371421-A1 Ligands of insulin degrading enzyme and their uses Université de Lille 2 Droit et Santé (FR) 2011-10-05 — — EP disclosed