Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.50 |
| ▸ | PDE4A | P27815 | 8/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29940033 | 1.00 | KDM4E (0.61) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL24735678 | 1.00 | KDM4E (0.61) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30278221 | 0.89 | PDE4D (0.54) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL28868065 | 0.89 | PDE4D (0.51) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL28868070 | 0.89 | PDE4D (0.51) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL24735664 | 0.89 | PDE4D (0.54) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL24735723 | 0.86 | PDE4D (0.48) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL24735661 | 0.86 | PDE4D (0.48) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL24735739 | 0.84 | PDE4D (0.49) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL24735738 | 0.84 | PDE4D (0.49) | KDM4EPDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022258057-A1 | COMPOUNDS AS ANTICANCER AGENTS | JINGRUI BIOPHARMA CO., LTD. (CN) | 2022-12-15 | — | — | WO | disclosed |
| CN-115215869-A | Substituted tricyclic inhibitor and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-115215844-A | Substituted pyrimido-ring inhibitor and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-10-21 | — | — | CN | disclosed |