Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.51 |
| ▸ | PDE4A | P27815 | 10/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28868070 | 1.00 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL30278221 | 0.90 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL24735664 | 0.90 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL24735678 | 0.89 | KDM4E (0.61) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL24735855 | 0.89 | KDM4E (0.61) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL29940033 | 0.89 | KDM4E (0.61) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL7355745 | 0.85 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL29059038 | 0.85 | LCK (0.60) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL29059040 | 0.85 | LCK (0.60) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6990530 | 0.85 | MAPK8 (0.41) | PDE4DPDE4APDE4BPDE4CMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115215869-A | Substituted tricyclic inhibitor and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-115215844-A | Substituted pyrimido-ring inhibitor and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-10-21 | — | — | CN | disclosed |