Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24736762 | 0.89 | RIPK1 (0.34) | RIPK1KDM4EPOLBNTRK1NTRK2 | |
| SCHEMBL24736761 | 0.89 | RIPK1 (0.34) | RIPK1KDM4EPOLBNTRK1NTRK2 | |
| SCHEMBL23822963 | 0.80 | CYP2D6 (0.40) | RIPK1 | |
| SCHEMBL24736807 | 0.78 | RIPK1 (0.34) | RIPK1KDM4EPOLBNTRK1NTRK2 | |
| SCHEMBL25852329 | 0.77 | SLC1A3 (0.35) | RIPK1KDM4EPOLBNTRK1NTRK2 | |
| SCHEMBL24736771 | 0.74 | RIPK1 (0.34) | RIPK1KDM4EPOLBNTRK1NTRK2 | |
| SCHEMBL24736759 | 0.74 | RIPK1 (0.34) | RIPK1KDM4EPOLBNTRK1NTRK2 | |
| SCHEMBL24736754 | 0.74 | RIPK1 (0.34) | RIPK1KDM4EPOLBNTRK1NTRK2 | |
| SCHEMBL5076546 | 0.70 | MAP4K4 (0.39) | RIPK1KDM4E | |
| SCHEMBL18666950 | 0.69 | CA1 (0.39) | RIPK1KDM4EPOLBMAPTRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022221514-A1 | METHODS OF PREPARING CARBANUCLEOSIDES USING AMIDES | GILEAD SCIENCES, INC. (US) | 2022-10-20 | — | — | WO | disclosed |