SCHEMBL24740458 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	P2RX3	P56373	1/20	0.51

▸	GPR119	Q8TDV5	1/20	0.44

▸	HRH3	Q9Y5N1	3/20	0.43

▸	KCNH2	Q12809	2/20	0.43

▸	MCL1	Q07820	11/20	0.42

▸	NR1H2	P55055	1/20	0.41

▸	NR1H3	Q13133	1/20	0.41

▸	PTPN1	P18031	1/20	0.41

▸	GRIN1	Q05586	1/20	0.40

▸	GRIN2B	Q13224	1/20	0.40

▸	CYP1A2	P05177	1/20	0.39

▸	POLB	P06746	1/20	0.39

▸	CYP3A4	P08684	1/20	0.39

▸	CYP2C19	P33261	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL12442648	0.89	P2RX3 (0.52)	P2RX3HRH3KCNH2MCL1NR1H2
SCHEMBL18617461	0.89	P2RX3 (0.52)	P2RX3HRH3KCNH2MCL1NR1H2
SCHEMBL18754654	0.89	P2RX3 (0.52)	P2RX3HRH3KCNH2MCL1NR1H2
SCHEMBL29523156	0.89	P2RX3 (0.52)	P2RX3HRH3KCNH2MCL1NR1H2
SCHEMBL24739408	0.87	HRH3 (0.54)	P2RX3HRH3KCNH2MCL1NR1H2
SCHEMBL3263994	0.87	P2RX3 (0.63)	P2RX3MCL1
SCHEMBL22112497	0.86	P2RX3 (0.43)	P2RX3GPR119HRH3KCNH2MCL1
SCHEMBL2434896	0.86	P2RX3 (0.50)	P2RX3MCL1NR1H2NR1H3PTPN1
SCHEMBL6846804	0.85	P2RX3 (0.53)	P2RX3HRH3KCNH2MCL1NR1H2
SCHEMBL25365111	0.85	P2RX3 (0.53)	P2RX3MCL1NR1H2NR1H3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022253101-A1	PYRIDAZINONE COMPOUND AS PARP7 INHIBITOR	上海优理惠生医药有限公司	2022-12-08	—	—	WO	disclosed