Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.37 |
| ▸ | ITGAL | P20701 | 3/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24739046 | 1.00 | TIPARP (0.42) | TIPARPTACR1SPHK2ITGB2ICAM1 | |
| SCHEMBL24739045 | 0.90 | POLB (0.39) | TIPARPITGB2ICAM1ITGALCHRNB2 | |
| SCHEMBL24740461 | 0.90 | POLB (0.39) | TIPARPITGB2ICAM1ITGALCHRNB2 | |
| SCHEMBL24740462 | 0.86 | TIPARP (0.64) | TIPARP | |
| SCHEMBL24739041 | 0.86 | TIPARP (0.64) | TIPARP | |
| SCHEMBL24740409 | 0.85 | THRA (0.35) | FFAR1RXRARXRBRXRGS1PR1 | |
| SCHEMBL24739382 | 0.81 | FFAR1 (0.35) | FFAR1RXRARXRBRXRGS1PR1 | |
| SCHEMBL24739385 | 0.80 | TIPARP (0.54) | TIPARPAADAT | |
| SCHEMBL28914953 | 0.79 | TIPARP (0.46) | TIPARPTACR1FFAR1 | |
| SCHEMBL28914956 | 0.79 | TIPARP (0.46) | TIPARPTACR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253101-A1 | PYRIDAZINONE COMPOUND AS PARP7 INHIBITOR | 上海优理惠生医药有限公司 | 2022-12-08 | — | — | WO | disclosed |