SCHEMBL24740863

SCHEMBL24740863

CNC(=O)c1ccc(-c2cn3c(n2)sc2cc(NC(=O)C4CCNCC4)ccc23)cc1

nearest known ligand 0.54

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 6/20 0.54
▸ RXFP1 Q9HBX9 2/20 0.54
▸ THRB P10828 4/20 0.49
▸ TP53 P04637 2/20 0.49
▸ MAPT P10636 2/20 0.49
▸ POLB P06746 1/20 0.49
▸ APP P05067 1/20 0.47
▸ FLT3 P36888 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24619522 0.88 LMNA (0.46) LMNARXFP1THRBTP53MAPT
SCHEMBL29924714 0.88 LMNA (0.46) LMNARXFP1THRBTP53MAPT
SCHEMBL24619447 0.84 LMNA (0.70) LMNARXFP1THRBTP53MAPT
SCHEMBL24619985 0.84 LMNA (0.47) LMNARXFP1THRBTP53MAPT
SCHEMBL24619975 0.82 LMNA (0.57) LMNARXFP1THRBTP53MAPT
SCHEMBL24619496 0.81 LMNA (0.65) LMNARXFP1THRBTP53MAPT
SCHEMBL24619490 0.81 LMNA (0.65) LMNARXFP1THRBTP53MAPT
SCHEMBL24741290 0.81 LMNA (0.67) LMNARXFP1THRBTP53MAPT
SCHEMBL24619415 0.78 LMNA (0.60) LMNARXFP1THRBTP53MAPT
SCHEMBL29924748 0.78 LMNA (0.60) LMNARXFP1THRBTP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024010762-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2024-01-11 — — WO disclosed
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2022-11-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 LMNA 1484/4885RXFP1 4840/4885THRB 2134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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