Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | F2R | P25116 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13469124 | 0.83 | MAPT (0.59) | SMN1; SMN2LMNAPARP1ALDH1A1F2R | |
| SCHEMBL4611142 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPARP1ALDH1A1F2R | |
| SCHEMBL6110283 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPARP1ACKR3ALDH1A1 | |
| SCHEMBL25144628 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAPARP1ACKR3ALDH1A1 | |
| SCHEMBL22096292 | 0.80 | RAB9A (0.59) | SMN1; SMN2LMNAPARP1ALDH1A1F2R | |
| SCHEMBL26785129 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAPARP1ACKR3ALDH1A1 | |
| SCHEMBL6108608 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAPARP1ACKR3ALDH1A1 | |
| SCHEMBL2474193 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAPARP1ACKR3ALDH1A1 | |
| SCHEMBL3466415 | 0.76 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAALDH1A1F2RL3MBTL1 | |
| SCHEMBL18100124 | 0.76 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAALDH1A1F2RL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265583-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-10-12 | — | — | EP | disclosed |
| EP-2265583-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-12-29 | — | — | EP | disclosed |
| US-7723372-B2 | Spiroindolinone derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-05-25 | — | — | US | disclosed |
| WO-2009115425-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-24 | — | — | WO | disclosed |
| US-20090239889-A1 | Spiroindolinone Derivatives | LIU JIN-JUN | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239889-A1 | Spiroindolinone Derivatives | CCNY, RB1, NQO1 | SMN1; SMN2 2488/4885LMNA 674/4885PARP1 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.