Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30115547 | 1.00 | BRD4 (0.46) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL24744055 | 0.90 | MAPT (0.41) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL30115595 | 0.89 | BRD4 (0.46) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL24744389 | 0.89 | BRD4 (0.46) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL24744361 | 0.88 | MAP2 (0.42) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL30115520 | 0.86 | HPGD (0.41) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL30115786 | 0.86 | LMNA (0.49) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL24744057 | 0.86 | HPGD (0.41) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL24744060 | 0.86 | LMNA (0.49) | BRD4HPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL24744751 | 0.85 | CCNC (0.44) | BRD4HPGDL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022254464-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AS METALLO-BETA-LACTAMASE INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-12-08 | — | — | WO | disclosed |