SCHEMBL24744448

SCHEMBL24744448

COc1cccc2c1C(=O)N(C1CCC(=O)N(C)C1=O)C2=O

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 13/20 0.49
CRBN Q96SW2 13/20 0.49
TNF P01375 1/20 0.42
IL1B P01584 1/20 0.42
TBXA2R P21731 1/20 0.42
IKZF1 Q13422 1/20 0.42
IKZF3 Q9UKT9 1/20 0.42
DRD2 P14416 2/20 0.41
EGFR P00533 1/20 0.40
HCRTR2 O43614 2/20 0.40
HTR1A P08908 1/20 0.40
HPGDS O60760 1/20 0.39
HCRTR1 O43613 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14085399 0.92 DDB1 (0.47) DDB1CRBNTNFIL1BTBXA2R
SCHEMBL20578897 0.84 DDB1 (0.52) DDB1CRBNTNFIL1BTBXA2R
SCHEMBL22940384 0.84 CRBN (0.62) DDB1CRBNTNFIL1BTBXA2R
SCHEMBL9988681 0.84 DDB1 (0.60) DDB1CRBNTNFIL1BTBXA2R
SCHEMBL21635225 0.83 CRBN (0.67) DDB1CRBNEGFRHPGDS
SCHEMBL28674408 0.82 DDB1 (0.48) DDB1CRBNTNFIL1BTBXA2R
SCHEMBL32679446 0.82 CRBN (0.60) DDB1CRBNTNFIL1BTBXA2R
SCHEMBL21196697 0.82 DDB1 (0.60) DDB1CRBNTNFIL1BTBXA2R
SCHEMBL21062845 0.82 CRBN (0.60) DDB1CRBNTNFIL1BTBXA2R
SCHEMBL12041893 0.81 CRBN (0.53) DDB1CRBNTNFIL1BTBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023115149-A1 BIFUNCTIONAL SULPHONAMIDE COMPOUNDS Anaxis Pharma Pty Ltd (AU) 2023-06-29 WO disclosed
WO-2023115150-A1 BIFUNCTIONAL ARYLSULPHONAMIDE COMPOUNDS Anaxis Pharma Pty Ltd (AU) 2023-06-29 WO disclosed
WO-2023078813-A1 HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS MERCK PATENT GMBH (DE) 2023-05-11 WO disclosed
WO-2022255888-A1 TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN CAPTOR THERAPEUTICS S.A. (PL) 2022-12-08 WO disclosed
WO-2022253713-A1 TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN CAPTOR THERAPEUTICS S.A. (PL) 2022-12-08 WO disclosed