Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 3/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24745731 | 0.82 | KDM4E (0.42) | LMNATP53HTTSMN1; SMN2MAPT | |
| SCHEMBL9847099 | 0.79 | TLR8 (0.72) | TLR8TP53HTTSMN1; SMN2MAPT | |
| SCHEMBL8016313 | 0.79 | TLR8 (0.67) | TLR8LMNATP53HTTSMN1; SMN2 | |
| SCHEMBL9847098 | 0.75 | TLR8 (0.57) | TLR8LMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL24744940 | 0.72 | MAPT (0.41) | LMNATP53HTTMAPTALDH1A1 | |
| SCHEMBL31090549 | 0.72 | MAPT (0.41) | LMNATP53HTTMAPTALDH1A1 | |
| SCHEMBL5371056 | 0.72 | SMN1; SMN2 (0.63) | LMNATP53HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5374092 | 0.72 | SMN1; SMN2 (0.63) | LMNATP53HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5377374 | 0.72 | SMN1; SMN2 (0.63) | LMNATP53HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5381431 | 0.72 | SMN1; SMN2 (0.63) | LMNATP53HTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |