Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 15/20 | 0.53 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23108626 | 1.00 | HRH4 (0.53) | HRH4DOT1LROCK2ROCK1CDC42BPB | |
| SCHEMBL23504191 | 1.00 | HRH4 (0.53) | HRH4DOT1LROCK2ROCK1CDC42BPB | |
| SCHEMBL22795991 | 0.86 | ROCK2 (0.46) | HRH4ROCK2ROCK1CDC42BPB | |
| SCHEMBL20255284 | 0.84 | HRH4 (0.45) | HRH4ROCK2ROCK1 | |
| SCHEMBL4827822 | 0.84 | CHRNB2 (0.51) | HRH4DOT1L | |
| SCHEMBL4828913 | 0.84 | CHRNB2 (0.52) | HRH4DOT1LROCK2ROCK1CDC42BPB | |
| SCHEMBL4822898 | 0.84 | CHRNB2 (0.51) | HRH4DOT1L | |
| SCHEMBL4828769 | 0.84 | CHRNB2 (0.52) | HRH4DOT1LROCK2ROCK1CDC42BPB | |
| SCHEMBL25372803 | 0.83 | KMT2A (0.53) | ROCK1CDC42BPB | |
| SCHEMBL23497669 | 0.83 | KMT2A (0.53) | ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |