Captan

Captan

SCHEMBL2474650

CC(O)CO.O=C1C2CC=CCC2C(=O)N1SC(Cl)(Cl)Cl

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Captan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.73
TSHR P16473 3/20 0.73
LMNA P02545 2/20 0.73
TP53 P04637 2/20 0.73
HTT P42858 2/20 0.73
KMT2A Q03164 2/20 0.73
HSD17B10 Q99714 2/20 0.73
CYP3A4 P08684 1/20 0.73
HPGD P15428 1/20 0.73
ALOX15 P16050 1/20 0.73
MAPK1 P28482 1/20 0.73
HIF1A Q16665 1/20 0.73
SMN1; SMN2 Q16637 2/20 0.38
NPSR1 Q6W5P4 2/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CA9 Q16790 3/20 0.31
CA12 O43570 2/20 0.31
CA1 P00915 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Captan SCHEMBL2988537 0.86 ALDH1A1 (0.86) ALDH1A1TSHRLMNATP53HTT
Captan SCHEMBL9668531 0.76 ALDH1A1 (0.68) ALDH1A1TSHRLMNATP53HTT
Captan SCHEMBL22126911 0.75 ALDH1A1 (0.76) ALDH1A1TSHRLMNATP53HTT
SCHEMBL22931 0.73 ALDH1A1 (0.69) ALDH1A1TSHRLMNATP53HTT
Fluoromethane SCHEMBL4198867 0.73 ALDH1A1 (0.63) ALDH1A1TSHRLMNATP53HTT
Captan SCHEMBL8530962 0.72 TSHR (0.61) ALDH1A1TSHRLMNATP53HTT
SCHEMBL20873426 0.72 ALDH1A1 (0.67) ALDH1A1TSHRLMNATP53HTT
Captan SCHEMBL8409894 0.71 ALDH1A1 (0.69) ALDH1A1TSHRLMNATP53HTT
Probucol SCHEMBL9450637 0.71 ALOX15 (0.59) ALDH1A1TSHRLMNATP53HTT
Benzene SCHEMBL192784 0.71 ALDH1A1 (0.65) ALDH1A1TSHRLMNATP53HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2373295-A2 STEROIDAL COMPOSITIONS Lipocine Inc. (US) 2011-10-12 EP disclosed
WO-2010081032-A2 STEROIDAL COMPOSITIONS LIPOCINE, INC. (US) 2010-07-15 WO disclosed
EP-1165048-A4 COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF IONIZABLE HYDROPHOBIC THERAPEUTIC AGENTS LIPOCINE INC (US) 2007-12-05 EP disclosed
EP-1210063-A4 COMPOSITIONS AND METHODS FOR ENHANCED ABSORPTION OF HYDROPHILIC THERAPEUTIC AGENTS LIPOCINE INC (US) 2007-08-15 EP disclosed
EP-1194120-A4 CLEAR OIL-CONTAINING PHARMACEUTICAL COMPOSITIONS LIPOCINE INC (US) 2005-06-15 EP disclosed
EP-1158959-A4 COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF HYDROPHOBIC THERAPEUTIC AGENTS LIPOCINE INC (US) 2004-12-08 EP disclosed
WO-2003068186-A1 PHARMACEUTICAL FORMULATIONS AND SYSTEMS FOR IMPROVED ABSORPTION AND MULTISTAGE RELEASE OF ACTIVE AGENTS LIPOCINE, INC. (US) 2003-08-21 WO disclosed
EP-1210063-A1 COMPOSITIONS AND METHODS FOR ENHANCED ABSORPTION OF HYDROPHILIC THERAPEUTIC AGENTS Lipocine, Inc. (US) 2002-06-05 EP disclosed
EP-1194120-A1 CLEAR OIL-CONTAINING PHARMACEUTICAL COMPOSITIONS Lipocine, Inc. (US) 2002-04-10 EP disclosed
EP-1165048-A1 COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF IONIZABLE HYDROPHOBIC THERAPEUTIC AGENTS Lipocine, Inc. (US) 2002-01-02 EP disclosed
EP-1158959-A1 COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF HYDROPHOBIC THERAPEUTIC AGENTS Lipocine, Inc. (US) 2001-12-05 EP disclosed
WO-2001012155-A1 COMPOSITIONS AND METHODS FOR ENHANCED ABSORPTION OF HYDROPHILIC THERAPEUTIC AGENTS LIPOCINE, INC. (US) 2001-02-22 WO disclosed
WO-2001001960-A1 CLEAR OIL-CONTAINING PHARMACEUTICAL COMPOSITIONS LIPOCINE, INC. (US) 2001-01-11 WO disclosed
WO-2000059475-A1 COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF IONIZABLE HYDROPHOBIC THERAPEUTIC AGENTS LIPOCINE, INC. (US) 2000-10-12 WO disclosed
WO-2000050007-A1 COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF HYDROPHOBIC THERAPEUTIC AGENTS LIPOCINE, INC. (US) 2000-08-31 WO disclosed