Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CPS1 | P31327 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29891362 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL24745853 | 0.88 | MEN1 (0.53) | GAAHPGDKDM4EKMT2AMEN1 | |
| SCHEMBL24745881 | 0.87 | MEN1 (0.54) | GAAHPGDKDM4EKMT2AMEN1 | |
| SCHEMBL24745867 | 0.85 | HPGD (0.41) | GAAHPGDKMT2AMEN1POLB | |
| SCHEMBL24746079 | 0.84 | HPGD (0.48) | SMN1; SMN2HPGDNPSR1KMT2AMEN1 | |
| SCHEMBL24746241 | 0.84 | MEN1 (0.53) | GAAHPGDKDM4EKMT2AMEN1 | |
| SCHEMBL24745854 | 0.82 | HPGD (0.46) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL10060722 | 0.81 | CPS1 (0.44) | SMN1; SMN2HPGDPOLBALDH1A1TSHR | |
| SCHEMBL24746242 | 0.80 | HPGD (0.43) | GAAHPGDNPSR1L3MBTL1KMT2A | |
| SCHEMBL24746182 | 0.78 | HPGD (0.42) | SMN1; SMN2HPGDNPSR1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |