Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CPS1 | P31327 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30630172 | 0.85 | MEN1 (0.64) | SMN1; SMN2GAAHPGDMEN1KMT2A | |
| SCHEMBL24747200 | 0.85 | MEN1 (0.64) | SMN1; SMN2GAAHPGDMEN1KMT2A | |
| SCHEMBL24747196 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2GAAHPGDL3MBTL1MEN1 | |
| SCHEMBL29891362 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2GAAHPGDL3MBTL1MEN1 | |
| SCHEMBL24747198 | 0.76 | HPGD (0.56) | SMN1; SMN2GAAHPGDMEN1KMT2A | |
| SCHEMBL30630165 | 0.76 | HPGD (0.56) | SMN1; SMN2GAAHPGDMEN1KMT2A | |
| SCHEMBL16962644 | 0.75 | TSHR (0.50) | NPSR1KDM4EHSD17B10TSHR | |
| SCHEMBL20561803 | 0.75 | TSHR (0.50) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL2105339 | 0.74 | HPGD (0.74) | SMN1; SMN2GAAHPGDMEN1KMT2A | |
| SCHEMBL15652689 | 0.73 | NPSR1 (0.60) | SMN1; SMN2HPGDALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |