Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25316992 | 0.76 | ALDH1A1 (0.32) | ALDH1A1NPSR1CA2KDM4EMEN1 | |
| SCHEMBL30853184 | 0.74 | CA2 (0.33) | ALDH1A1NPSR1CA2KDM4EMEN1 | |
| SCHEMBL24748775 | 0.74 | CA2 (0.33) | ALDH1A1NPSR1CA2KDM4EMEN1 | |
| SCHEMBL25316126 | 0.74 | HCRTR1 (0.31) | ALDH1A1NPSR1HCRTR1HCRTR2KDM4E | |
| SCHEMBL30853192 | 0.74 | CA2 (0.33) | ALDH1A1NPSR1CA2KDM4EMEN1 | |
| SCHEMBL24748724 | 0.69 | HCRTR1 (0.33) | HCRTR1HCRTR2MEN1MAPTHPGD | |
| SCHEMBL29183067 | 0.69 | CA2 (0.33) | ALDH1A1NPSR1CA2HCRTR2MEN1 | |
| SCHEMBL28252204 | 0.69 | HDAC4 (0.36) | ALDH1A1 | |
| SCHEMBL28668136 | 0.68 | — | — | |
| SCHEMBL30931250 | 0.68 | POLB (0.47) | ALDH1A1TP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022256679-A1 | N-(HYDROXYALKYL (HETERO)ARYL) TETRAHYDROFURAN CARBOXAMIDE ANALOGS AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |