Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780241 | 0.81 | CYP3A4 (0.56) | HRH3HRH4HTR3A | |
| SCHEMBL13897023 | 0.81 | CYP3A4 (0.49) | HRH3HRH4HTR3AITGB2ICAM1 | |
| SCHEMBL27756059 | 0.78 | HRH3 (0.51) | HRH3EPHX2EPHX1HRH4HTR3A | |
| SCHEMBL2474956 | 0.76 | CYP19A1 (0.39) | EPHX1CYP19A1 | |
| Phloroglucinol SCHEMBL27988573 | 0.75 | HTR1D (0.46) | HRH3HRH4HTR3AITGB2ICAM1 | |
| SCHEMBL1641647 | 0.75 | CYP3A4 (0.51) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL13979576 | 0.75 | CYP3A4 (0.51) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL27043238 | 0.75 | ITGB2 (0.60) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL163397 | 0.75 | ITGB2 (0.60) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL31326521 | 0.74 | CYP3A4 (0.54) | HRH3HRH4ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9511120-B2 | Use of the angiotensin-(1-9) peptide or derivatives thereof, use of vectors overexpressing the ACE2 enzyme that produces angiotensin-(1-9) for preparing medicaments useful for preventing, reverting, inhibiting and/or reducing hypertension and/or inducing vasodilation | PONTIFICA UNIVERSIDAD CATÓLICA DE CHILE (CL) | 2016-12-06 | — | — | US | disclosed |
| US-9132164-B2 | Pharmaceutical compositions comprising angiotensin-(1-9), derivatives thereof, or a vector expressing ACE2, useful for treating cardiovascular, pulmonary, cerebral, and/or renal remodeling | PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) | 2015-09-15 | — | — | US | disclosed |
| US-20150190472-A1 | USE OF THE ANGIOTENSIN-(1-9) PEPTIDE OR DERIVATIVES THEREOF, USE OF VECTORS OVEREXPRESSING THE ACE2 ENZYME THAT PRODUCES ANGIOTENSIN-(1-9) FOR PREPARING MEDICAMENTS USEFUL FOR PREVENTING, REVERTING, INHIBITING AND/OR REDUCING HYPERTENSION AND/OR INDUCING VASODILATION | PONTIFICA UNIVERSIDAD CATOLICA DE CHILE (CL) | 2015-07-09 | — | — | US | disclosed |
| EP-2377544-B1 | PHARMACEUTICAL COMPOSITION CONTAINING ANGIOTENSIN-(1-9) FOR CARDIOVASCULAR, PULMONARY AND/OR CEREBRAL TREATMENT | PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) | 2014-10-22 | — | — | EP | disclosed |
| US-20120172301-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING ANGIOTENSIN-(1-9), DERIVATIVES THEREOF, OR A VECTOR EXPRESSING ACE2, USEFUL FOR TREATING CARDIOVASCULAR, PULMONARY, CEREBRAL, AND/OR RENAL REMODELING | PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) | 2012-07-05 | — | — | US | disclosed |
| EP-2377544-A2 | PHARMACEUTICAL COMPOSITION CONTAINING ANGIOTENSIN-(1-9) FOR CARDIOVASCULAR, PULMONARY AND/OR CEREBRAL TREATMENT | Pontificia Universidad Católica De Chile (CL) | 2011-10-19 | — | — | EP | disclosed |