SCHEMBL24749733

SCHEMBL24749733

COc1ccc(Oc2ccc(Cl)c(Cl)c2)cc1N

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.59
MEN1 O00255 2/20 0.59
MAPT P10636 2/20 0.59
KMT2A Q03164 2/20 0.59
THRB P10828 1/20 0.59
HTR2A P28223 10/20 0.49
SLC6A4 P31645 10/20 0.49
KCNH2 Q12809 8/20 0.49
HSP90AA1 P07900 1/20 0.47
GAA P10253 2/20 0.47
CYP3A4 P08684 1/20 0.47
NR4A1 P22736 1/20 0.44
NPC1 O15118 1/20 0.43
KDM4E B2RXH2 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
HPGD P15428 1/20 0.42
CYP2C19 P33261 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31694884 1.00 ALDH1A1 (0.59) ALDH1A1MEN1MAPTKMT2ATHRB
SCHEMBL27949499 0.88 HTR2A (0.58) ALDH1A1MEN1MAPTKMT2ATHRB
SCHEMBL15938210 0.87 ALDH1A1 (0.76) ALDH1A1MEN1MAPTKMT2ATHRB
SCHEMBL5862483 0.85 HTR2A (0.54) HTR2ASLC6A4KCNH2HSP90AA1
SCHEMBL31694879 0.85 MAPT (0.54) ALDH1A1MEN1MAPTKMT2ATHRB
SCHEMBL24750327 0.85 ALDH1A1 (0.54) ALDH1A1MEN1MAPTKMT2ATHRB
SCHEMBL24749736 0.85 MAPT (0.54) ALDH1A1MEN1MAPTKMT2ATHRB
SCHEMBL24750329 0.84 ALDH1A1 (0.61) ALDH1A1MEN1MAPTKMT2ATHRB
SCHEMBL24749620 0.82 AR (0.55) ALDH1A1MEN1MAPTKMT2ATHRB
SCHEMBL31009385 0.80 MAPT (0.56) ALDH1A1MEN1MAPTKMT2ATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022219246-A1 TEAD INHIBITORS ORION CORPORATION (FI) 2022-10-20 WO disclosed