SCHEMBL2475201

SCHEMBL2475201

COc1cc2c(=O)cc(/C=N/O)[nH]c2c2ncccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC40A1 Q9NP59 2/20 0.38
CYP1A1 P04798 4/20 0.36
CYP1B1 Q16678 4/20 0.36
CYP1A2 P05177 3/20 0.36
ATM Q13315 1/20 0.36
GLA P06280 1/20 0.36
GAA P10253 1/20 0.36
KDM4E B2RXH2 4/20 0.35
NSD2 O96028 2/20 0.35
CASP6 P55212 2/20 0.35
G6PD P11413 1/20 0.35
MAPT P10636 2/20 0.35
POLB P06746 1/20 0.35
MEN1 O00255 2/20 0.34
HSP90AA1 P07900 2/20 0.34
KMT2A Q03164 2/20 0.34
MMP10 P09238 2/20 0.34
NPC1 O15118 1/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2475206 1.00 SLC40A1 (0.38) SLC40A1CYP1A1CYP1B1CYP1A2ATM
SCHEMBL2472983 0.86 SLC40A1 (0.41) SLC40A1CYP1A1CYP1B1CYP1A2ATM
SCHEMBL12027643 0.85 CCR1 (0.40) SLC40A1GAAKDM4EMAPTMEN1
SCHEMBL12047086 0.80 SLC40A1 (0.43) SLC40A1CYP1A1CYP1B1CYP1A2ATM
SCHEMBL8446262 0.78 GLA (0.48) SLC40A1CYP1A1CYP1B1CYP1A2ATM
SCHEMBL2475302 0.78 SLC40A1 (0.40) SLC40A1CYP1A1CYP1B1CYP1A2ATM
SCHEMBL2469641 0.77 GLA (0.62) SLC40A1CYP1A1CYP1B1CYP1A2ATM
SCHEMBL12027712 0.71 CCR1 (0.44) SLC40A1CYP1B1CYP1A2KDM4EMAPT
SCHEMBL3454980 0.69 HSP90AA1 (0.44) SLC40A1ATMGAAKDM4ENSD2
SCHEMBL13372636 0.69 HSP90AA1 (0.44) SLC40A1ATMGAAKDM4ENSD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2373650-B1 TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER NOSCIRA SA (ES) 2012-10-24 EP disclosed
EP-2373650-B1 TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER NOSCIRA SA (ES) 2012-10-24 EP disclosed
US-20110306631-A1 TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER NOSCIRA, S.A. (ES) 2011-12-15 US disclosed
US-20110306631-A1 TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER NOSCIRA, S.A. (ES) 2011-12-15 US disclosed
EP-2373650-A1 TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER Noscira, S.A. (ES) 2011-10-12 EP disclosed
WO-2010066832-A1 TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER NOSCIRA, S.A. (ES) 2010-06-17 WO disclosed
WO-2010066832-A1 TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER NOSCIRA, S.A. (ES) 2010-06-17 WO disclosed
EP-2196466-A1 Triple substituted phenanthroline derivatives for the treatment of neurodegenerative or heamatological diseases or conditions NOSCIRA, S.A. (ES) 2010-06-16 EP disclosed
EP-2196466-A1 Triple substituted phenanthroline derivatives for the treatment of neurodegenerative or heamatological diseases or conditions NOSCIRA, S.A. (ES) 2010-06-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110306631-A1 TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER HTT, PFN1, PSEN1 SLC40A1 575/4885CYP1A1 1510/4885CYP1B1 1726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.