Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.37 |
| ▸ | PDE4A | P27815 | 7/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24752107 | 0.85 | PDE4B (0.42) | PDE4BCA12CA1CA2CA7 | |
| SCHEMBL16618391 | 0.79 | KMT2A (0.42) | PDE4BKMOCA12CA1CA2 | |
| SCHEMBL15573836 | 0.78 | CA12 (0.63) | PDE4BCA12CA1CA2CA4 | |
| SCHEMBL29189599 | 0.78 | PDE4B (0.43) | PDE4BKMOCA12CA1CA2 | |
| SCHEMBL12492024 | 0.77 | PDE4B (0.46) | PDE4BKMOCA12CA1CA2 | |
| SCHEMBL2593591 | 0.77 | RAB9A (0.55) | PDE4BKMOCA12CA1CA2 | |
| SCHEMBL29189643 | 0.76 | PDE4B (0.41) | PDE4BKMOCA12CA1CA2 | |
| SCHEMBL29189597 | 0.75 | CASP6 (0.56) | ALDH1A1TSHR | |
| SCHEMBL16510466 | 0.73 | CA12 (0.65) | CA12CA1CA2CA4CA6 | |
| SCHEMBL24287952 | 0.73 | PDE4A (0.43) | PDE4BCA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263472-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-12-22 | — | — | WO | disclosed |
| EP-4105218-A1 | SUBSTITUTED PYRROLO[2,3-D] PYRIMIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-12-21 | — | — | EP | disclosed |