Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | DAO | P14920 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29763764 | 1.00 | MEN1 (0.46) | MEN1KMT2ADAONTRK1PIN1 | |
| SCHEMBL24752309 | 0.86 | MEN1 (0.39) | MEN1KMT2ANTRK1KDM4EALDH1A1 | |
| SCHEMBL30853010 | 0.85 | ABL1 (0.42) | KDM4E | |
| SCHEMBL24752055 | 0.85 | ABL1 (0.42) | KDM4E | |
| SCHEMBL28705638 | 0.84 | FGFR1 (0.40) | MEN1KMT2ANTRK1SMN1; SMN2 | |
| SCHEMBL20980339 | 0.84 | KDM4E (0.43) | MEN1KMT2ANTRK1KDM4EALDH1A1 | |
| SCHEMBL28514657 | 0.81 | MEN1 (0.35) | MEN1KMT2ANTRK1KDM4EALDH1A1 | |
| SCHEMBL10323760 | 0.81 | KDM6B (0.50) | MEN1KMT2ANTRK1KDM4EHPGD | |
| SCHEMBL28839534 | 0.76 | DAO (0.45) | MEN1KMT2ADAOPIN1KDM4E | |
| SCHEMBL30808517 | 0.76 | DAO (0.45) | MEN1KMT2ADAOPIN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117881681-A | Substituted pyrrolo [2,3-d ] pyrimidines, their preparation and their therapeutic use | 赛诺菲 | 2024-04-12 | — | — | CN | disclosed |
| WO-2022263472-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-12-22 | — | — | WO | disclosed |
| EP-4105218-A1 | SUBSTITUTED PYRROLO[2,3-D] PYRIMIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-12-21 | — | — | EP | disclosed |
| CN-113788837-B | Trilaciclib synthesis method | 深圳湾实验室坪山生物医药研发转化中心 | 2022-08-26 | — | — | CN | disclosed |
| CN-113788837-A | Trilaciclib synthesis method | 深圳湾实验室坪山生物医药研发转化中心 | 2021-12-14 | — | — | CN | disclosed |