Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28705638 | 0.83 | FGFR1 (0.40) | MEN1KMT2ASMN1; SMN2NTRK1NUDT1 | |
| SCHEMBL20980339 | 0.83 | KDM4E (0.43) | MEN1KMT2AMAPTAHRKDM4E | |
| SCHEMBL29763764 | 0.81 | MEN1 (0.46) | MEN1KMT2AMAPTAHRSMN1; SMN2 | |
| SCHEMBL24752128 | 0.81 | MEN1 (0.46) | MEN1KMT2AMAPTAHRSMN1; SMN2 | |
| SCHEMBL24752309 | 0.80 | MEN1 (0.39) | MEN1KMT2AMAPTAHRKDM4E | |
| SCHEMBL24752055 | 0.79 | ABL1 (0.42) | KDM4E | |
| SCHEMBL30853010 | 0.79 | ABL1 (0.42) | KDM4E | |
| SCHEMBL28527857 | 0.77 | TLR9 (0.35) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL10323760 | 0.69 | KDM6B (0.50) | MEN1KMT2AAHRKDM4EALDH1A1 | |
| SCHEMBL5458537 | 0.69 | NPC1 (0.45) | MEN1KMT2AAHRALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112375081-A | Pyrrole [2,3-d ] pyrimidine derivative with CDK4, 6 or 9 inhibiting activity and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2021-02-19 | — | — | CN | disclosed |