Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ASPH | Q12797 | 2/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | KDM4A | O75164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 5/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15306831 | 0.93 | KDM4E (0.41) | SMN1; SMN2KDM4EASPHKDM8L3MBTL1 | |
| SCHEMBL3194003 | 0.83 | KDM4E (0.41) | SMN1; SMN2KDM4EASPHKDM8L3MBTL1 | |
| SCHEMBL21818593 | 0.79 | ACHE (0.40) | SMN1; SMN2KDM4EASPHKDM8L3MBTL1 | |
| SCHEMBL31133522 | 0.79 | KDM4E (0.38) | SMN1; SMN2KDM4EASPHKDM8L3MBTL1 | |
| SCHEMBL21819163 | 0.79 | KDM4E (0.38) | SMN1; SMN2KDM4EASPHKDM8L3MBTL1 | |
| SCHEMBL3581100 | 0.78 | PARP1 (0.47) | KDM4EL3MBTL1TDP1ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL3585465 | 0.77 | PARP1 (0.46) | KDM4EL3MBTL1TDP1ALDH1A1TSHR | |
| SCHEMBL24752130 | 0.76 | KDM4C (0.35) | KDM4EASPHKDM8KDM4AKDM5A | |
| SCHEMBL24469508 | 0.76 | BUB1 (0.30) | — | |
| SCHEMBL27138365 | 0.75 | KDM4E (0.40) | SMN1; SMN2KDM4EASPHKDM8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4105218-A1 | SUBSTITUTED PYRROLO[2,3-D] PYRIMIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-12-21 | — | — | EP | disclosed |