Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32679331 | 0.79 | HDAC1 (0.47) | HDAC1HDAC6SMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL9595456 | 0.75 | KMT2A (0.66) | SMN1; SMN2ALDH1A1HPGDMGLLKMT2A | |
| SCHEMBL24754375 | 0.74 | ALDH1A1 (0.44) | HDAC1HDAC6SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24754376 | 0.74 | BRD4 (0.41) | HDAC1HDAC6SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL23516966 | 0.74 | ALDH1A1 (0.50) | HDAC1HDAC6SMN1; SMN2ALDH1A1DRD2 | |
| SCHEMBL3274471 | 0.73 | CA1 (0.55) | SMN1; SMN2ALDH1A1HPGDEPHX2NR1H4 | |
| SCHEMBL24018194 | 0.73 | TP53 (0.57) | SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL1004649 | 0.72 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1HPGDEPHX2NR1H4 | |
| SCHEMBL23517936 | 0.72 | EP300 (0.45) | HDAC1HDAC6SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL505778 | 0.71 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1HPGDEPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263829-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY | Z Factor Limited (GB) | 2022-12-22 | — | — | WO | disclosed |