Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24754229 | 0.77 | HDAC1 (0.46) | BRD4DRD2TBXA2RGAAKMT2A | |
| SCHEMBL24754236 | 0.75 | HDAC1 (0.46) | ALDH1A1BRD4DRD2TBXA2RGAA | |
| SCHEMBL24754261 | 0.70 | BRD4 (0.50) | MAPK14SMN1; SMN2BRD4GAAKMT2A | |
| SCHEMBL505778 | 0.69 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2HPGDEPHX2NR1H4 | |
| SCHEMBL24754227 | 0.69 | HDAC1 (0.44) | MAPK14ALDH1A1SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL24754376 | 0.69 | BRD4 (0.41) | MAPK14ALDH1A1SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL24754375 | 0.69 | ALDH1A1 (0.44) | CECR2ALDH1A1SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL3274471 | 0.68 | CA1 (0.55) | ALDH1A1SMN1; SMN2HPGDEPHX2NR1H4 | |
| SCHEMBL24754399 | 0.68 | HDAC1 (0.46) | ALDH1A1SMN1; SMN2HPGDDRD2KMT2A | |
| SCHEMBL24755097 | 0.68 | ALDH1A1 (0.39) | MAPK14CECR2ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263829-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY | Z Factor Limited (GB) | 2022-12-22 | — | — | WO | disclosed |