Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GRM8 | O00222 | 2/20 | 0.36 |
| ▸ | GRM6 | O15303 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25955125 | 0.79 | APLNR (0.50) | APLNRGABRR1CYP2C19GRM4CYP1A2 | |
| SCHEMBL18868469 | 0.69 | CYP2D6 (0.36) | APLNRCYP2C19CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL18868470 | 0.69 | CYP2D6 (0.36) | APLNRCYP2C19CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL23673375 | 0.68 | TSHR (0.46) | APLNRCYP2C19GRM4CYP1A2ALDH1A1 | |
| SCHEMBL10179248 | 0.68 | GABRP (0.42) | APLNRGABRR1CYP2C19GRM4CYP1A2 | |
| SCHEMBL3492010 | 0.66 | — | — | |
| SCHEMBL5807559 | 0.66 | — | — | |
| SCHEMBL3492014 | 0.66 | — | — | |
| SCHEMBL6734957 | 0.66 | — | — | |
| SCHEMBL1824346 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263817-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY | Z Factor Limited (GB) | 2022-12-22 | — | — | WO | disclosed |