Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.72 |
| ▸ | HTR1A | P08908 | 1/20 | 0.72 |
| ▸ | DRD4 | P21917 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zalospirone SCHEMBL247562 | 1.00 | DRD2 (0.72) | DRD2HTR1ADRD4 | |
| Zalospirone SCHEMBL17256233 | 1.00 | DRD2 (0.72) | DRD2HTR1ADRD4 | |
| Zalospirone SCHEMBL9526873 | 1.00 | DRD2 (0.72) | DRD2HTR1ADRD4 | |
| Zalospirone SCHEMBL13532604 | 1.00 | DRD2 (0.72) | DRD2HTR1ADRD4 | |
| Zalospirone SCHEMBL3374045 | 1.00 | DRD2 (0.72) | DRD2HTR1ADRD4 | |
| Zalospirone SCHEMBL123826 | 0.99 | DRD2 (0.72) | DRD2HTR1ADRD4 | |
| SCHEMBL9527393 | 0.91 | DRD2 (0.71) | DRD2HTR1ADRD4 | |
| SCHEMBL9528185 | 0.91 | DRD2 (0.71) | DRD2HTR1ADRD4 | |
| SCHEMBL17264052 | 0.91 | DRD2 (0.71) | DRD2HTR1ADRD4 | |
| SCHEMBL13534443 | 0.91 | DRD2 (0.71) | DRD2HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 873 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154967-B1 | PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES | JOHNSON MATTHEY PLC (GB) | 2020-07-29 | — | — | EP | claimed |
| CN-109745323-A | Azapirone compound improves the active purposes of parasympathetic nerve | 四川科瑞德制药股份有限公司 | 2019-05-14 | — | — | CN | claimed |
| US-20180099982-A1 | PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES | MACFARLAN SMITH LIMITED (GB) | 2018-04-12 | — | — | US | claimed |
| EP-3154967-A1 | PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES | Johnson Matthey Public Limited Company (GB) | 2017-04-19 | — | — | EP | claimed |
| CN-105636438-A | Pharmaceutical composition comprising an AMPK activator and a serotonin active agent and uses thereof | CHEN JIANHONG | 2016-06-01 | — | — | CN | claimed |
| EP-2983473-A2 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS Mountain Llc (US) | 2016-02-17 | — | — | EP | claimed |
| EP-2086544-B1 | USE OF TESTOSTERONE AND A 5-HT1A AGONIST IN THE TREATMENT OF SEXUAL DYSFUNCTION | EB IP LYBRIDOS B V (NL) | 2015-12-23 | — | — | EP | claimed |
| WO-2015195478-A1 | PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2015-12-23 | — | — | WO | claimed |
| US-20150361099-A1 | PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES | MACFARLAN SMITH LIMITED (GB) | 2015-12-17 | — | — | US | claimed |
| US-20150328221-A1 | COMPOUNDS FOR PROTECTION OF PHOTORECEPTOR CELLS AND FOR ENHANCING VISUAL FUNCTION UNDER LOW LIGHT CONDITIONS | ALLERGAN INC (US) | 2015-11-19 | — | — | US | claimed |
| US-6331536-B1 | ADMINISTERING TO PATIENT IN NEED THEREOF EFFECTIVE AMOUNT OF SEROTONIN RECEPTOR ANTAGONIST TO PREVENT OR AMELIORATE SLEEP-RELATED BREATHING DISORDER | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2001-12-18 | — | — | US | claimed |
| US-6312717-B1 | ANTIDEPRESSANTS OR ANTI ANXIETY BY ADMINISTERING AZAPIRONE AND 5-HT1A AUTOSOMAL RECEPTOR ANTAGONIST | BRISTOL-MYERS SQUIBB COMPANY | 2001-11-06 | — | — | US | claimed |
| EP-1066036-A1 | AGENTS WITH SEROTONIN-RELATED ACTIVITY FOR THE TREATMENT FOR SLEEP APNEA | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2001-01-10 | — | — | EP | claimed |
| WO-2000006160-A1 | TREATING DEPRESSION WITH A COMBINATION OF FLUOXETINE (PROZAC), PINDOLOL (VISKEN) AND BUSPIRONE (BUSPAR) | SANOFI-SYNTHELABO (FR) | 2000-02-10 | — | — | WO | claimed |
| WO-2000006163-A1 | IMPROVED METHOD FOR TREATMENT OF SLEEP-RELATED RESPIRATORY DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-02-10 | — | — | WO | claimed |
| EP-0969842-A1 | PHARMACEUTICAL COMPOSITION | R.P. Scherer Limited (GB) | 2000-01-12 | — | — | EP | claimed |
| WO-1999043319-A1 | AGENTS WITH SEROTONIN-RELATED ACTIVITY FOR THE TREATMENT FOR SLEEP APNEA | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1999-09-02 | — | — | WO | claimed |
| WO-1999013879-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING A MONOAMINE OXYDASE INHIBITOR AND THEIR USE IN THERAPY | SANOFI-SYNTHELABO (FR) | 1999-03-25 | — | — | WO | claimed |
| WO-1998042344-A1 | PHARMACEUTICAL COMPOSITION | R. P. SCHERER LIMITED (GB) | 1998-10-01 | — | — | WO | claimed |
| WO-1997041878-A1 | TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE | MERCK & CO., INC. (US) | 1997-11-13 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099982-A1 | PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES | NR5A2, NR4A3, NR4A2 | DRD2 110/4885HTR1A 270/4885DRD4 51/4885 |
| US-20150361099-A1 | PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES | NR5A2, NR4A3, NR4A2 | DRD2 110/4885HTR1A 270/4885DRD4 51/4885 |
| US-20150328221-A1 | COMPOUNDS FOR PROTECTION OF PHOTORECEPTOR CELLS AND FOR ENHANCING VISUAL FUNCTION UNDER LOW LIGHT CONDITIONS | NR2E3, GRK1, PDE6C | DRD2 364/4885HTR1A 828/4885DRD4 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.