⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24906374 | 0.86 | KMT2A (0.33) | — | |
| SCHEMBL24906394 | 0.76 | SCN10A (0.44) | — | |
| SCHEMBL24757296 | 0.76 | SCN10A (0.44) | — | |
| SCHEMBL24757299 | 0.76 | SCN10A (0.44) | — | |
| SCHEMBL24757255 | 0.76 | RXRA (0.34) | — | |
| SCHEMBL30975999 | 0.75 | RXRA (0.33) | — | |
| SCHEMBL30141508 | 0.74 | CHRM2 (0.31) | — | |
| SCHEMBL24758965 | 0.73 | — | — | |
| SCHEMBL24757758 | 0.73 | CHRM2 (0.31) | — | |
| SCHEMBL27243076 | 0.73 | CHRM2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |