Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766055 | 0.76 | PIM1 (0.49) | LRRK2ATRMAPTTSHRMAPK1 | |
| SCHEMBL29434132 | 0.76 | PIM1 (0.49) | LRRK2ATRMAPTTSHRMAPK1 | |
| SCHEMBL17204101 | 0.76 | MAPT (0.61) | MAPTTSHRMAPK1NPSR1HSD17B10 | |
| SCHEMBL24766035 | 0.75 | MAPT (0.43) | ATRPIK3CAMAPTTSHRMAPK1 | |
| SCHEMBL24766568 | 0.74 | ATR (0.57) | ATR | |
| SCHEMBL24766591 | 0.73 | CNR2 (0.46) | PIK3CAMAPTTSHRMAPK1NPSR1 | |
| SCHEMBL24766072 | 0.73 | PIM1 (0.52) | LRRK2PIK3CAMAPTTSHRMAPK1 | |
| SCHEMBL24766032 | 0.72 | PIK3CA (0.51) | PIK3CAMAPTAKT1MTORCYP1A2 | |
| SCHEMBL29434160 | 0.72 | MAPT (0.65) | MAPTTSHRMAPK1NPSR1HSD17B10 | |
| SCHEMBL29434159 | 0.72 | MAPT (0.65) | MAPTTSHRMAPK1NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340543-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2022-10-27 | — | — | US | disclosed |
| US-11407737-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2022-08-09 | — | — | US | disclosed |
| US-11407737-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2022-08-09 | — | — | US | disclosed |
| US-20220089569-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2022-03-24 | — | — | US | disclosed |
| WO-2022060996-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340543-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | LRRK2 416/4885PRKD1 590/4885PRKD2 544/4885 |
| US-11407737-B2 | Inhibitors of RAF kinases | BRAF, RAF1, ARAF | LRRK2 416/4885PRKD1 590/4885PRKD2 544/4885 |
| US-20220089569-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | LRRK2 416/4885PRKD1 590/4885PRKD2 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.