Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 4/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766055 | 1.00 | PIM1 (0.49) | PIM1LRRK2CCNCCDK8ATR | |
| SCHEMBL3262674 | 0.87 | LRRK2 (0.49) | PIM1LRRK2CCNCCDK8ATR | |
| SCHEMBL24766072 | 0.85 | PIM1 (0.52) | PIM1LRRK2MAPTKMT2ATSHR | |
| SCHEMBL24766049 | 0.78 | ROCK2 (0.40) | RAF1BRAF | |
| SCHEMBL29434090 | 0.78 | ROCK2 (0.40) | RAF1BRAF | |
| SCHEMBL24766067 | 0.76 | LRRK2 (0.48) | LRRK2ATRMAPTKMT2ATSHR | |
| SCHEMBL24766059 | 0.76 | ATR (0.47) | LRRK2ATRATRIPMAPTKMT2A | |
| SCHEMBL17204101 | 0.76 | MAPT (0.61) | MAPTKMT2ATSHRMAPK1NPSR1 | |
| SCHEMBL3261500 | 0.74 | RET (0.44) | PIM1LRRK2FGFR3KDRKMT2A | |
| SCHEMBL24766572 | 0.73 | KMT2A (0.44) | RAF1MAPTKMT2ANPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060996-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-03-24 | — | — | WO | disclosed |